Application | Comment | Organism |
---|---|---|
medicine | cleavage by ADAM10 of beta-amyloid precursor protein could abolish production of longer peptides and slow down or arrest Alzheimer disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell associated | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein | Homo sapiens | LoVo cell line overexpressing ADAM10 secreted a 185% of sAPP-alpha over control values | sAPP-alpha fragment + C-terminal fragment | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
cell line | - |
Purification (Comment) | Organism |
---|---|
SDS-PAGE | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney cell line | wild type cell line | Homo sapiens | - |
LoVo cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein | LoVo cell line overexpressing ADAM10 secreted a 185% of sAPP-alpha over control values | Homo sapiens | sAPP-alpha fragment + C-terminal fragment | - |
? |